Evorel Patches

How to order Evorel patches online:

• Complete a short online assessment to see if you’re eligible for treatment
• Reviewed by one of our clinicians
• If approved, we post it to you with tracked delivery and discreetly

Evorel is a hormone replacement therapy (HRT) patch used to relieve symptoms of menopause and perimenopause caused by falling oestrogen levels, such as hot flushes, night sweats and mood changes. You wear it on your skin, and it releases estradiol, a form of oestrogen, over several days.

Evorel patches come in four strengths, each releasing a different amount of estradiol over 24 hours:

• Evorel 25: contains 1.6mg estradiol, releasing 25 micrograms every 24 hours
• Evorel 50: contains 3.2mg estradiol, releasing 50 micrograms every 24 hours
• Evorel 75: contains 4.8mg estradiol, releasing 75 micrograms every 24 hours
• Evorel 100: contains 6.4mg estradiol, releasing 100 micrograms every 24 hours

Evorel is oestrogen-only. If you still have a womb, you’ll usually need a separate progestogen medicine alongside it to protect the lining of your womb; Evorel on its own is generally only suitable if you’ve had a hysterectomy, or you’ve had no bleeding for at least 12 months on a cyclical HRT regimen.

Evorel isn’t a contraceptive. If it’s been less than 12 months since your last period, or you’re under 50, you may still need additional contraception to avoid pregnancy. Don’t use a hormonal contraceptive alongside HRT.

Evorel delivers oestrogen steadily through the skin and into your bloodstream, which helps ease symptoms such as hot flushes, night sweats, vaginal dryness and low mood.

Oestrogen on its own can cause the womb lining to thicken over time, which raises the risk of endometrial changes and, in rare cases, cancer. That’s why a progestogen is normally added for women with a uterus. It’s taken either cyclically, causing a regular withdrawal bleed similar to a period, or continuously so that there’s no bleeding at all. Your clinician will advise which regimen suits you.

Use Evorel patches twice a week, so each patch stays on for three to four days. For symptom relief, treatment usually starts with one Evorel patch, with the dose adjusted after the first month depending on your symptoms and whether you notice signs of too much oestrogen, such as breast tenderness.

The maximum dosage allowed is 100 mcg every 24 hours.

• Apply the patch to clean, dry, healthy skin on your trunk, below the waist.
• Use a slightly different area of skin each time.
• Don’t apply it on or near the breasts.
• You can leave the patch on while you bathe or shower.
• If it falls off in the bath or shower, wait until your skin has cooled down, then put on a replacement to avoid absorbing too much oestrogen too quickly.
• If it falls off at any other time, replace it straight away.
• If any sticky residue is left on your skin after removing a patch, baby oil can help remove it.

Change it as soon as you remember and apply the next one at your usual time. If it’s almost time for your next change, skip the missed one and carry on as normal. Only ever wear one patch at a time.

Most women notice an improvement in menopausal symptoms within a few weeks of starting treatment, though it can take longer for your body to settle into a new dose fully. If your symptoms haven’t improved enough after a few months, or you’re getting side effects, your dose or patch strength can be adjusted. Don’t change your dose without speaking to your prescriber first.

Who shouldn’t use Evorel patches?

Don’t use Evorel if you:

• are allergic to estradiol or any of the other ingredients
• have or ever had breast cancer
• have had a cancer that’s made worse by oestrogen, such as endometrial cancer
• have unexplained vaginal bleeding
• have untreated thickening of the womb lining (endometrial hyperplasia)
• have ever had a blood clot in a vein (thrombosis), or a clot that travelled to your lung (pulmonary embolism)
• have a blood clotting disorder, such as protein C, protein S or antithrombin deficiency
• have had liver disease
• have had a heart attack, angina or a stroke caused by blocked arteries
• have porphyria

If you’re not sure whether any of these apply to you, talk to your doctor or a pharmacist before starting Evorel. Stop using Evorel patches and speak to your doctor straight away if any of the above develops for the first time while you’re using it.

If Evorel isn’t suitable for you or you’d like to explore other options, we offer a range of alternative HRT treatments, including:

• Evorel Conti
• Evorel Sequi
• Sandrena Gel
• Elleste Duet
• Elleste Solo
• Elleste Duet Conti
• Kliovance
• Femoston
• Estriol
• Lenzetto Spray

We wouldn’t recommend it without your doctor’s specific instruction. The estradiol in Evorel patches is distributed evenly through the adhesive, so cutting them can make the treatment less effective.

NHS guidance on cutting transdermal patches advises you to do this only when a doctor has specifically instructed it, since manufacturers can’t guarantee the dose is spread evenly across a cut patch, and doing so isn’t part of Evorel’s licensed use.

If your prescribed strength isn’t working for you, then talk to our clinical team about switching to a different Evorel strength before you do anything.

Apply Evorel to clean, dry, healthy skin on your trunk below the waist; the buttocks, hips, and lower abdomen all work well. Avoid your breasts, and skip any skin that’s irritated, broken, or sits under tight waistbands or elasticated clothing, as friction can make your Evorel patch lift at the edges.

Change where you place each patch rather than reusing the same spot, and leave at least a week before applying a patch to the same area again. This gives your skin time to recover and reduces the chance of irritation building up.

Weight gain is a possible side effect, but the NHS states there’s little evidence that most types of HRT make you put on weight, and that any weight gain around this stage of life often happens whether or not you’re taking HRT, largely due to metabolic changes that come with menopause itself. Some women notice bloating in the first few weeks of using a new patch, which can feel like weight gain. This usually settles as your body adjusts; if you’re concerned, mention it at your next review.

Yes, Evorel is designed to stay in place through normal bathing, showering and everyday activity. If a patch comes away in the bath or shower, wait until your skin has cooled and any redness from the warm water has settled before applying a replacement. Putting a new patch on warm, flushed skin can mean you absorb too much oestrogen too quickly.

Very hot water, saunas, steam rooms or prolonged swimming sessions can increase the chances of a patch lifting at the edges, so check it’s still firmly stuck on after any of these activities. If your patch falls off outside of bathing, replace it straight away.

• Side effects of hormone replacement therapy. (HRT). (2023) NHS. [Accessed 5 October 2026]
• Menopause and perimenopause. (2026) NHS. [Accessed 5 October 2026]
• Evorel Patches: Summary of Product Characteristics. (2026) Electronic Medicines Compendium. [Accessed 5 October 2026]
• Evorel Patches: Patient Information Leaflet. (2025) Electronic Medicines Compendium. [Accessed 5 October 2026]
• Cutting or masking transdermal patches safely. (2025) NHS Specialist Pharmacy Service. [Accessed 5 October 2026]
• Menopause: identification and management. (NG23). ([Year]) NICE. [Accessed 5 October 2026]
• Yellow Card: making medicines and medical devices safer. (n.d.) MHRA. [Accessed 5 October 2026]