Tadalafil vs Sildenafil: Which One Is Right For You?

Don’t let erectile dysfunction (ED) get in the way of your sex life this 2026. Discover a treatment option that works for you; getting that confidence back and feeling like yourself again. So when it comes to choosing the correct medication, which is best? When it comes to erectile dysfunction treatments the two standout medications are tadalafil and sildenafil as the most popular and most effective options. But how do you know which one is right for you?

This guide delves into the differences of tadalafil and sildenafil, exploring how they work, their benefits, and their side effects. To help make your decision easier.

What is tadalafil?

Tadalafil (brand names Cialis and Avarante) is a medication used for treating ED. It belongs to a class of drugs known as phosphodiesterase type 5 (PDE5) inhibitors, which also include sildenafil, vardenafil, and avanafil.

One of the features of tadalafil is its long duration of action. It can remain effective for up to 36 hours, earning it the nickname “The Weekend Pill”. This longer duration offers a great advantage for those who desire more spontaneity in their sexual activity, as it doesn’t require as precise timing as sildenafil tablets.

The recommended starting dose for tadalafil is typically 10 mg, taken at least 30 minutes before sexual activity. However, the dosage may vary based on individual response and tolerability, and it can also be prescribed for daily use in a lower dose, offering more flexibility and spontaneity for the user.

How Tadalafil works

Tadalafil (and other PDE5 inhibitors) help to relax the blood vessels in the penis and prostate area. This relaxation allows for better blood flow to the penis, helping to achieve and maintain an erection during sexual activity.

It’s important to remember that sexual stimulation is required for tadalafil to be effective during sexual activity. The medication does not lead to an erection without sexual arousal.

Tadalafil’s effectiveness can last up to 36 hours, providing a wider window of opportunity for sexual activity compared to other ED medications.

Tadalafil is not a one size fits all medication. Individuals with certain health conditions or those taking specific medications, especially nitrates used for heart conditions may not be eligible for this medication. This is why all those wishing to purchase tadalafil are required to fill out a The Family Chemist consultation to ensure safety.

Benefits of Tadalafil

• Long-lasting: Tadalafil can remain effective for up to 36 hours, offering a larger window for sexual activity without the need for timing.
• Flexibility: Available in both low-dose forms for daily use and higher doses for use as needed, offering flexibility for different lifestyles and preferences.
• Effective: Demonstrates a high efficacy rate in treating erectile dysfunction, helping to achieve and maintain an erection.
• Fast-Acting: Starts working within 30-45 minutes of intake, making it a great option for planned sexual activity.
• Spontaneity in sexual activities: Due to its long-lasting effect, it allows for more spontaneity compared to other ED medications that require more precise timing.
• Well-tolerated: Generally well-tolerated, with most side effects being mild and temporary, such as headache, back pain, or nasal congestion.
• Can be taken with or without food: Unlike certain medications, food intake does not significantly affect its efficacy.
• Proven track record: Widely studied and used, with a proven safety and efficacy track record.

What is Sildenafil?

Sildenafil (brand names Viagra and Hezkue) has gained significant attention for its effectiveness in improving sexual function in men with ED.

Sildenafil works in a similar way to tadalafil, by inhibiting the enzyme phosphodiesterase type 5 (PDE5). This inhibition leads to increased levels of cyclic guanosine monophosphate (cGMP) in the smooth muscle cells of the penis. cGMP is a critical biochemical mediator responsible for relaxing soft muscle tissue, and its increased levels result in the dilation of blood vessels and improved blood flow to the penis. This process is crucial in achieving and maintaining an erection suitable for sexual intercourse.

How Sildenafil works

Sildenafil, primarily known for treating erectile dysfunction (ED), works through a specific biochemical process:

• Inhibits Phosphodiesterase Type 5 (PDE5): Sildenafil targets and inhibits PDE5, an enzyme found in various body tissues, most prominently in the smooth muscle tissue of the penis.
• Increases cGMP levels: By inhibiting PDE5, Sildenafil prevents the breakdown of cyclic guanosine monophosphate (cGMP). cGMP is a molecule that controls the dilation and contraction of blood vessels.
• Enhances blood flow to the penis: The increased levels of cGMP lead to relaxed, smooth muscles and dilated blood vessels in the penis. This improved blood flow is crucial for achieving and maintaining an erection.
• Requires sexual stimulation: It’s important to note that sildenafil facilitates erections only if sexually aroused. It doesn’t cause spontaneous erections or increase sexual desire.
• Duration of effectiveness: The effects of sildenafil typically last for about 4 to 6 hours, offering a significant window for sexual activity.

The new oral spray 

For those who may struggle with an oral tablet form of medication and are still wishing to find an appropriate treatment for their erectile dysfunction; Hezkue might be a better option. Containing sildenafil, yet in an easy to use, fast acting oral spray that can be used on the go.

Benefits of Sildenafil

1. Effective for erectile dysfunction: Sildenafil has a high success rate in treating ED, helping men to achieve and maintain an erection sufficient for sexual activity.
2. Rapid onset of action: It typically begins to work within 30 to 60 minutes, making it a practical option for those planning sexual activity.
3. Duration of effectiveness: The effects of Sildenafil can last for up to 4 to 6 hours, providing a considerable window for spontaneity in sexual encounters.
4. Well-researched and trusted: Sildenafil has been extensively studied and is widely recognised as a safe and effective treatment for ED, with a well-established safety profile.
5. Psychological benefits: By effectively treating ED, Sildenafil can significantly improve sexual confidence, reduce stress, and enhance overall quality of life.
6. Easy to administer: Available in oral tablet form and as the new oral spray form, there options for those who may find traditional tablet swallowing more difficult. 
7. Suitable for most men with ED: Sildenafil is generally well-tolerated and can be used by a wide range of men with ED, except for those with certain medical conditions or those taking specific medications.
8. Generic availability: Generic versions are available, making them more accessible and affordable for many patients.

Comparing tadalafil and sildenafil

Effectiveness

Tadalafil (Cialis) is notable for its long-lasting effects. It remains effective for up to 36 hours, offering a wide window for spontaneity. This longer duration makes tadalafil a preferred option for those wanting flexibility and less need for planning sexual activities.

Sildenafil (Viagra) has a shorter duration of effectiveness, typically around 4 to 6 hours. It is known for its rapid onset, usually lasting 30 to 60 minutes. This makes sildenafil suitable for those who desire a quick onset of action.

Both medications have similar success rates in treating ED, varying effectiveness based on individual response and health factors. Tadalafil’s once-daily option, available in lower doses, is ideal for men who prefer readiness for sexual activity at any time. In contrast, sildenafil is often chosen for its quick action and proven track record.

Sildenafil effectiveness with age

Duration

Tadalafil and sildenafil, both used to treat erectile dysfunction, differ in their longevity, impacting how they are used. Tadalafil is renowned for its extended duration of action. It can remain effective for up to 36 hours after ingestion, which is a key distinguishing feature. This allows spontaneity, as it doesn’t require planning for sexual activity. Users can take it well in advance and still experience its benefits.

On the other hand, sildenafil has a shorter duration of effectiveness. It typically lasts for about 4 to 6 hours. This shorter duration means that sildenafil needs to be taken closer to the time of planned sexual activity. Its rapid onset of action, within 30 to 60 minutes of taking the medication, makes it suitable for more immediate use.

The choice between the two often depends on the user’s preference for spontaneity versus timing, with tadalafil offering a longer window for unplanned activities and Sildenafil being ideal for more immediate, planned encounters.

Side effects

When comparing the side effects of tadalafil and sildenafil, it’s important to note that both medications, as PDE5 inhibitors, share several common side effects due to their similar mechanism of action in treating erectile dysfunction. However, there are also some differences in their side-effect profiles:

Common side effects of both tadalafil and sildenafil:

• Headaches: Headaches are one of the most common side effects resulting from the changes in blood flow caused by the medication.
• Flushing: Both can cause temporary skin redness, typically on the face and neck.
• Indigestion or heartburn: Digestive issues can occur as a side effect.
• Nasal congestion: Results from the dilation of blood vessels in the nasal passages.
• Back pain and muscle aches (more common with tadalafil): Tadalafil users might experience muscle and back pain, which usually resolves within 48 hours.
• Vision Changes: Slight changes in colour perception, blurred vision, or sensitivity to light may occur, more commonly with sildenafil.
• Dizziness: This can occur due to the changes in blood pressure.

Unique or more prominent side effects:

• Prolonged erection (Priapism): Rare but more commonly associated with sildenafil.
• Gastrointestinal problems: More commonly reported with tadalafil, particularly with higher doses.
• Skin rash: Rare but can be a side effect of sildenafil.

Duration-dependent side effects:

• Due to tadalafil’s extended duration, side effects like back pain and muscle aches might persist longer than with sildenafil.

The Bottom Line

Both Tadalafil and Sildenafil are effective treatments for erectile dysfunction. The differences between the two could make them more fitting depending on your lifestyle, how well they are tolerated, and personal preference. You should consult with a pharmacist if you are considering erectile dysfunction treatment, who can help find the best course of action that is suitable and safe for you.