Nitrofurantoin 100mg MR Capsules (Macrobid)

For uncomplicated cystitis, it is recommended to take one Nitrofurantoin 100mg capsule twice daily for three days, spacing the doses 12 hours apart—for example, at 8 am and 8 pm. Taking the medication with a meal or a milky drink can help prevent stomach upset.

While the manufacturer’s patient information leaflet might suggest a 7-day treatment course, the standard practice has shifted to a three-day course. Improvements are usually noticeable within 24 hours, and symptoms typically resolve after three days. If your symptoms do not improve or if they worsen, consulting a doctor is advisable.

When ordering medications like Nitrofurantoin, which is typically supplied in packs of 14 capsules, you may receive a plain box containing only a portion of these, such as 6 capsules, if the original pack cannot be split evenly. This practice ensures that you receive your medication as quickly and efficiently as possible. If you have any questions or concerns about your medication, please reach out for assistance.

Like any medication, nitrofurantoin may cause side effects, though most individuals tolerate it well. It’s important to be aware of potential adverse reactions:

• Gastrointestinal Disturbances: Common side effects include nausea, vomiting, diarrhea, and stomach pain. Taking nitrofurantoin with food can help mitigate these symptoms.
• Allergic Reactions: While rare, nitrofurantoin can trigger allergic reactions ranging from mild skin rashes to severe symptoms like difficulty breathing and swelling. Immediate medical attention is required if you experience any signs of an allergic reaction.
• Pulmonary Toxicity: Nitrofurantoin has been linked to lung-related side effects, such as pulmonary fibrosis, though these are rare. It’s crucial to report any unusual respiratory symptoms to your healthcare provider promptly.
• Peripheral Neuropathy: Prolonged use, especially at high doses, may lead to peripheral neuropathy, which is characterized by tingling, numbness, or weakness in the hands or feet. Contact your doctor if you experience such symptoms.

While nitrofurantoin is effective for treating urinary tract infections (UTIs), it’s important to follow certain precautions and recognize contraindications to ensure its safe and appropriate use:

• Allergic Reactions: Individuals allergic to nitrofurantoin or any of its components should not use this medication. Reactions can range from mild skin rashes to severe symptoms like difficulty breathing and swelling. Seek immediate medical attention if you experience signs of an allergic reaction.
• Severe Kidney Disease: As nitrofurantoin is primarily eliminated through the kidneys, those with severe kidney disease or renal impairment may not clear the medication effectively, increasing the risk of toxicity. Dosage adjustments or alternative treatments may be necessary.
• G6PD Deficiency: Nitrofurantoin can trigger hemolytic anemia in individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency—a genetic condition affecting red blood cell function. Use this medication with caution if you have G6PD deficiency.
• Lung Disease: Nitrofurantoin has been linked to lung issues, such as pulmonary fibrosis and pneumonitis. If you have pre-existing lung conditions like COPD or asthma.
• Pregnancy and Breastfeeding: Generally safe during the second and third trimesters, consult with our pharmacist before starting nitrofurantoin during pregnancy. While excreted in breast milk, it is usually considered compatible with breastfeeding, but consultation is advised.
• Elderly Patients: Older adults may be more susceptible to side effects such as peripheral neuropathy. Monitoring and possible dose adjustments may be necessary.
• Interactions with Other Medications: Nitrofurantoin can interact with other drugs, affecting efficacy or increasing side effects. Inform our pharmacist about all other medications you are taking.